An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and... - 0 views
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Although the prostate is an androgen-dependent tissue, estrogens influence both normal functions and pathological changes in this gland
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This dual action may be due to the existence of two estrogen receptors, ERα and ERβ
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ERα and ERβ have similar affinities for estradiol-17β
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3-beta androstanediola, a product of 3alpha-HSD from DHT binds to ER beta and down regulates AR in prostate cancer. This study proposes that the mechanism is via CYP7B1. CYP7B1 inactivates 3-beta androstanediol. Interesting, because 3-beta androstanediol is considered "inactive" when compared to 3-alpha androstanediol and its interaction with ER alpha.